Synthyra

Research library

Models.

The models behind our research products and design programs.

Browse by scientific role. Each page says what the model is for, where it fits, and what its outputs mean.

01

Foundation models

cdsBERT

A codon-aware protein modeling research direction for understanding coding-sequence effects.

codonsfoundation model

Dual Triangle Attention

A foundation-model research direction for stronger position-aware bidirectional sequence modeling.

attentionfoundation model

ESMC

EvolutionaryScale Biohub's ESM Cambrian model family, exposed through FastPLMs as ESM++ checkpoints.

protein language modelfoundation model

Vec2Vec

Aligns protein, annotation, and language-model representations so biological knowledge can move between spaces.

representation learningalignment

02

Platforms

04

Oracle models

EC General

Suggests broad enzyme-class hypotheses from protein sequence.

enzymeannotation

EC Rigor

Provides stricter enzyme-function hypotheses when higher-confidence EC assignment is needed.

enzymeannotation

E. coli Expression

Prioritizes proteins that are more likely to express successfully in E. coli workflows.

expressiondevelopability

Homodimer

Estimates whether a protein sequence is likely to self-associate as a homodimer.

interactionoligomer

Atlas Oracle Suite

A set of fast protein property predictors for triaging sequence quality, function, localization, and developability.

property predictioninterpretability

kcat

Estimates enzyme turnover potential from protein sequence.

enzymekinetics

pH Preference

Estimates the pH range where a protein may be most compatible or active.

pHenzyme

Realness

Scores whether a sequence looks like a natural protein rather than random or poorly formed sequence.

qualitynaturalness

Solubility

Prioritizes protein sequences that are more likely to remain soluble.

solubilitydevelopability

SoluProt

Provides a complementary solubility-style readout for protein developability triage.

solubilitydevelopability

Subcellular Localization

Predicts likely cellular localization signals from protein sequence.

localizationannotation

Taxon

Estimates taxonomic signal in a protein sequence for context, quality control, and dataset review.

taxonomyquality control

Temperature Stability

Estimates whether a protein sequence is likely to tolerate higher-temperature conditions.

stabilitydevelopability

Translator

Turns protein sequences into structured functional annotation hypotheses.

annotationfunction

Synthyra

Optimize the outcome, not the interface.

Biological design programs selected on the predicted state of the system, not the quality of one contact.

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